Anemia? Don't take folate until you watch this!
- Kevin Lowe M.D.
- 6 minutes ago
- 1 min read
Folate, also known as vitamin B9, is essential for DNA production and healthy red blood cell formation. But when someone has megaloblastic or unexplained macrocytic anemia, taking folic acid without considering vitamin B12 deficiency can sometimes hide an important clue. In this video, I explain how folate deficiency and vitamin B12 deficiency can both cause large red blood cells and megaloblastic anemia—and why telling the difference matters. Vitamin B12 deficiency can also affect the nervous system, causing numbness, tingling, weakness, balance problems, and, in severe cases, damage to the spinal cord. Folic acid can improve the anemia associated with vitamin B12 deficiency without treating the underlying B12 deficiency. That means the blood count may improve while neurological problems remain untreated.
You’ll learn:
What folate and folic acid do in the body
Why folate deficiency causes megaloblastic anemia
How vitamin B12 deficiency can look similar
Why B12 deficiency can cause neurological symptoms
Why vitamin B12 should be considered when evaluating macrocytic or megaloblastic anemia
The important message is not to avoid folate when it is medically indicated—particularly during pregnancy—but rather to understand why the anemia developed in the first place. Because when vitamin B12 deficiency is the real problem, fixing the blood count does not necessarily mean you have fixed the disease: https://youtu.be/tTmUgUTPszU



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