Stress is a normal physiologic response to stimuli perceived by a person to be threatening. When the expected outcome of a situation and reality do not correspond, this can cause inner tension and be perceived as a threat, generating stress.
Stress manifests as an increase in the heart rate, the rate of breathing, and sweating. These are accompanied by emotional manifestations of stress. The most common of these are a state of arousal, a feeling of detachment from the surroundings, and lack of focus.
The intensity of these symptoms is modulated by several factors. Cultural differences, how mental health is perceived in a particular group, what coping mechanisms are popularly utilized, and genetics. A living organism will respond to stressful situations according to the sensitivity of the nervous system to psychological and physical stimuli. A prime example is how the responses of men and women to stressful stimuli differ, with men seeing a greater activation of the sympathetic nervous system than women do.
The stress response is a physiological defense mechanism designed to protect the person. The initial response to stress is the release of noradrenalin in the nerve endings and activation of the hypothalamus-pituitary- adrenal axis (HPA axis). This causes the release of ACTH (adrenocorticotropic hormone) from the pituitary gland, which stimulates the adrenal gland to release cortisol into the circulation. These physiological responses cause the heart rate to increase, the muscles to tense up, the blood pressure to rise, and the rate of breathing to increase. This readies a person to confront perceived danger. If, however, this heightened state of readiness persists indefinitely, it can be harmful to the individual. The persistent flooding of the system with noradrenaline, adrenaline, and cortisol can lead to diseases such as high blood pressure, diabetes, and metabolic syndrome. People who react to stressful stimuli by suppressing their emotions can have their symptoms manifest at a later time with chronic headaches, chronic backache and gastrointestinal symptoms such as irritable bowel syndrome.
Stressful situations in childhood can affect how a person responds to stress as adults. Painful memories are vivid and stimuli that cause the recall of painful memories can trigger an intense stress response. Emotional memories, conscious or unconscious, can color the internal state of a person. This can often lead to irrational, unexpected, and unexplained outbursts as responses to seemingly benign stimuli. Stress responses can also be primed by the socioeconomic situation of a person, their state of health, their choice of foods, their sleep hygiene, and their exercise culture. The use of alcohol, cigarette smoking, or drug use can also influence the stress response negatively.
As stress and the pervasive arousal persist, health is adversely affected. Married couples in an argumentative and hostile marriage can see their health affected adversely as a result of the stress that exists in the relationship. Stress hormones, increase the coagulability of platelets, can lead to hyperresponsiveness of the vasculature, and hence, predispose the individual to heart attacks and strokes. The constant adrenergic stimulation can cause high blood pressure and heart disease. Persistently elevated levels of cortisol can cause high blood sugar and suppress the immune system. The suppressed immune system is a prescription for all kinds of infectious diseases, non-responsiveness to vaccines, and the development of cancers.
One extreme response to stress is sudden death in situations of intense fear. The underlying cause is an arrythmia resulting from hyperstimulation of the heart by sympathetic hormones and catecholamine toxicity. Stress is not an innocuous state that one should ignore. Stress requires effective management through development of stress management techniques, attention to overall health, reconfiguration of misperception and, in some cases, professional guidance.